Overcome Male Infertility & Complex Fertility Issues

If you have been diagnosed with male fertility problems, such as low sperm count or low sperm motility, IntraCytoplasmic Sperm Injection (ICSI) can help you conceive with IVF treatment. It is also recommended when there is no sperm in the semen, or if you have had a vasectomy, and we need to obtain the sperm surgically from the testes.


ICSI treatment is typically part of your IVF cycle – the difference is how fertilisation is achieved. Instead of adding the sperm to the egg, a skilled embryologist uses a very fine micromanipulation equipment to inject a single sperm into each egg.

Used together, IVF and ICSI are amongst the most common assisted reproductive techniques used around the world, and this advanced procedure has helped many thousands of couples achieve their dream of having a baby.

IMSI (Intracytoplasmic Morphologically-Selected Sperm Injection)

For men with severely reduced levels of sperm morphology (size and shape) or with mid-or-high range DNA damaged sperm, there is an increased risk of miscarriage and reduced clinical pregnancy rates – even with ICSI treatment. Other treatment options for these men, such as the surgical extraction of sperm (TESE), carry surgical risk and are relatively expensive.

For these patients, Virtus Fertility Centre Singapore offers Intracytoplasmic Morphologically-Selected Sperm Injection (IMSI) treatment, which allows the laboratory to enlarge the images of sperm to over 1,200 times its actual magnification. By comparison standard ICSI treatment only offers 200 to 400 times the magnification of sperm

The embryologist then uses pre-defined sperm sizes and shape to select the most appropriate sperm to be injected into the egg. This technique offers our patients a significant increase in fertilisation and pregnancy rates, and a reduction in miscarriage rates. Virtus Fertility Centre Singapore is the only fertility centre in Singapore to offer this technique to all patients.

Dr Liow Swee Lian explains the latest techniques for overcoming male infertility such as IntraCytoplasmic Sperm Injection (ICSI) and Intracytoplasmic Morphologically-Selected Sperm Injection (IMSI).